NO
On $150,000/yr, the typical $741,868 home in Boston, MA needs $218,720/yr ($5,103/mo). Your gap: $-68,720 — housing would be 40.8% of your gross income.
The math
741,868 price − 10% down (74,187) = 667,681 loan
30-yr fixed at 6.47% on 667,681 = 4,207/mo principal+interest
+ 896/mo est. taxes+insurance (1.45%/yr of value — national placeholder)
5,103/mo PITI ÷ 0.28 = 18,227/mo → 218,720/yr required
against Zillow ZHVI 2026-05 and the 6.47% FRED 30-yr rate (2026-06-18).
What salary WOULD clear Boston, MA?
You need about $218,720/yr for the typical home. That's $68,720 more than $150,000.