YES
On $4,125,000/yr, the typical $288,316 home in Buffalo, NY needs $85,148/yr ($1,987/mo). Your gap: +$4,039,852 — housing would be 0.6% of your gross income.
The math
288,316 price − 10% down (28,832) = 259,484 loan
30-yr fixed at 6.49% on 259,484 = 1,638/mo principal+interest
+ 348/mo est. taxes+insurance (1.45%/yr of value — national placeholder)
1,987/mo PITI ÷ 0.28 = 7,096/mo → 85,148/yr required
against Zillow ZHVI 2026-05 and the 6.49% FRED 30-yr rate (2026-06-25).
What salary WOULD clear Buffalo, NY?
You need about $85,148/yr for the typical home. On $4,125,000 you already clear it by $4,039,852.